Authors: (including presenting author): :
Kwan WY(1), Ho SW(1), Tsang WM(1), Shum R(1).
Affiliation: :
(1) Infection Control Team, Tseung Kwan O Hospital.
Keyword 1: :
Multidrug-Resistant Organisms (MDROs)
Keyword 2: :
Carbapenem-Resistant Acinetobacter (CRA)
Keyword 3: :
Infection Control
Keyword 4: :
Multicomponent Interventions
Keyword 5: :
Antimicrobial Resistance
Introduction: :
The resurgence of Carbapenem‑resistant Acinetobacter (CRA) threatens patient safety across acute‑care settings. Since 2025, an increasing trend in CRA clinical specimen and bloodstream infections were observed, prompting urgent action. Traditional single‑measure strategies proved insufficient. Therefore, a bundle of evidence‑based infection‑control interventions was adopted to control further transmission.
Objectives: :
-Evaluate the effectiveness of an integrated intervention bundle -Assess the impact of the intervention bundle on key infection‑control interventions.
Methodology: :
The project began in January 2025, comparing baseline statistics prior to the implementation of intervention. The bundle on key infection control metrics to confirmed CRA cases includes: 1. Hand hygiene: Enhance surveillance, compare the data between ward auditors and ICNs. Step up hand hygiene antiseptics with 0.5% Chlorhexidine Gluconate with 70% alcohol. 2. Dedicated use of medical equipment. 3. Chlorhexidine (CHG) bathing 4. Environmental cleansing: Review current measures, ensure the cleansing quality of cleansing staff and PCAs. Educate the importance of high touch areas cleansing. 5. Environmental sampling and UV fluorescence test: For quality control and clustering investigation. 6. Enhanced CRA screening for patients with a recent history of hospital admission 7. Antibiotic stewardship with audits
Result & Outcome: :
The integrated intervention bundle produced measurable improvements. The overall hand hygiene compliance rate across all staff categories maintained greater than 90%. The hand hygiene before meals compliance rate rose markedly in 4Q 2025. For environmental cleaning, the quality improved confirmed by environmental sampling and UV fluorescence testing. The combined measures correlated with a downward trend in new CRA cases since October 2025.
